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Effectiveness of transcranial magnetic therapy in the complex treatment of alcohol abstinent syndrome.
Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(9):57-61
Authors: Staroverov AT, Zhukov OB, Raĭgorodskiĭ IM
Fifty-four abstinent alcohol-dependent patients have been studied. Twenty-nine patients (a main group) received, along with basic therapy, a physiotherapeutic treatment (transcranial dynamic magnetic therapy) and 25 patients (a control group) received only basic therapy. The comparison of the efficacy of treatment in patients of the main and control groups revealed the benefits of transcranial dynamic magnetic therapy in CNS function, performance on memory and attention tests, state of autonomic nervous system and psychoemotional state of patients (the reduction of anxiety and depression).
PMID: 18833174 PubMed - as supplied by publisher
Pulsed Magnetic Therapy
magnetic therapy
Popularity: 27% [?]
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Substituted beta-cyclodextrin and calix4arene as encapsulatory vehicles for platinum(II)-based DNA intercalators.
Inorg Chem. 2008 Aug 4;47(15):6880-8
Authors: Krause-Heuer AM, Wheate NJ, Tilby MJ, Pearson DG, Ottley CJ, Aldrich-Wright JR
The encapsulation of three platinum(II)-based anticancer complexes, (5,6-dimethyl-1,10-phenanthroline)(1 S,2 S-diaminocyclohexane)platinum(II) (2+) ( 56MESS), (5,6-dimethyl-1,10-phenanthroline)(1 R,2 R-diaminocyclohexane)platinum(II) (2+) ( 56MERR), and (5,6-dimethyl-1,10-phenanthroline)(ethylenediamine)platinum(II) (2+) ( 56MEEN), with carboxylated-beta-cyclodextrin (c-beta-CD) and p-sulfonatocalix4arene (s-CX4) has been examined by one- and two-dimensional (1)H nuclear magnetic resonance (NMR) spectroscopy, pulsed gradient spin-echo NMR, ultraviolet spectrophotometry, glutathione degradation experiments, and growth inhibition assays. Titration of any of the three metal complexes with c-beta-CD resulted in 1:1 encapsulation complexes with the cyclodextrin located over the intercalating ligand of the metal complexes, with a binding constant of 10 (4)-10 (5) M (-1). In addition to binding over the phenanthroline ligand of 56MEEN, c-beta-CD was also found to portal bind to the ethylenediamine ligand, with fast exchange kinetics on the NMR timescale between the two binding sites. In contrast, the three metal complexes all formed 2:2 inclusion complexes with s-CX4 where the two metal complexes stacked in a head-to-tail configuration and were capped by the s-CX4 molecules. Interestingly, the 56MEEN-s-CX4 complex appeared to undergo a thermodynamically controlled rearrangement to a less soluble complex over time. Encapsulation of the metal complexes in either c-beta-CD or s-CX4 significantly decreased the metal complexes' rate of diffusion, consistent with the formation of larger particle volumes. Encapsulation of 56MESS within s-CX4 or c-beta-CD protected the metal complex from degradation by reduced L-glutathione, with a reaction half-life greater than 9 days. In vitro growth inhibition assays using the LoVo human colorectal cancer cell line showed no significant change in the cytotoxicity of 56MESS when encapsulated by either s-CX4 or c-beta-CD.
PMID: 18597414 PubMed - indexed for MEDLINE
Pulsed Magnetic Therapy
bio magnetic therapy
Popularity: 35% [?]
More info…
Substituted beta-cyclodextrin and calix4arene as encapsulatory vehicles for platinum(II)-based DNA intercalators.
Inorg Chem. 2008 Aug 4;47(15):6880-8
Authors: Krause-Heuer AM, Wheate NJ, Tilby MJ, Pearson DG, Ottley CJ, Aldrich-Wright JR
The encapsulation of three platinum(II)-based anticancer complexes, (5,6-dimethyl-1,10-phenanthroline)(1 S,2 S-diaminocyclohexane)platinum(II) (2+) ( 56MESS), (5,6-dimethyl-1,10-phenanthroline)(1 R,2 R-diaminocyclohexane)platinum(II) (2+) ( 56MERR), and (5,6-dimethyl-1,10-phenanthroline)(ethylenediamine)platinum(II) (2+) ( 56MEEN), with carboxylated-beta-cyclodextrin (c-beta-CD) and p-sulfonatocalix4arene (s-CX4) has been examined by one- and two-dimensional (1)H nuclear magnetic resonance (NMR) spectroscopy, pulsed gradient spin-echo NMR, ultraviolet spectrophotometry, glutathione degradation experiments, and growth inhibition assays. Titration of any of the three metal complexes with c-beta-CD resulted in 1:1 encapsulation complexes with the cyclodextrin located over the intercalating ligand of the metal complexes, with a binding constant of 10 (4)-10 (5) M (-1). In addition to binding over the phenanthroline ligand of 56MEEN, c-beta-CD was also found to portal bind to the ethylenediamine ligand, with fast exchange kinetics on the NMR timescale between the two binding sites. In contrast, the three metal complexes all formed 2:2 inclusion complexes with s-CX4 where the two metal complexes stacked in a head-to-tail configuration and were capped by the s-CX4 molecules. Interestingly, the 56MEEN-s-CX4 complex appeared to undergo a thermodynamically controlled rearrangement to a less soluble complex over time. Encapsulation of the metal complexes in either c-beta-CD or s-CX4 significantly decreased the metal complexes' rate of diffusion, consistent with the formation of larger particle volumes. Encapsulation of 56MESS within s-CX4 or c-beta-CD protected the metal complex from degradation by reduced L-glutathione, with a reaction half-life greater than 9 days. In vitro growth inhibition assays using the LoVo human colorectal cancer cell line showed no significant change in the cytotoxicity of 56MESS when encapsulated by either s-CX4 or c-beta-CD.
PMID: 18597414 PubMed - indexed for MEDLINE
Pulsed Magnetic Therapy
magnetic health
Popularity: 42% [?]
More info…
Effectiveness of transcranial magnetic therapy in the complex treatment of alcohol abstinent syndrome.
Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(9):57-61
Authors: Staroverov AT, Zhukov OB, Raĭgorodskiĭ IM
Fifty-four abstinent alcohol-dependent patients have been studied. Twenty-nine patients (a main group) received, along with basic therapy, a physiotherapeutic treatment (transcranial dynamic magnetic therapy) and 25 patients (a control group) received only basic therapy. The comparison of the efficacy of treatment in patients of the main and control groups revealed the benefits of transcranial dynamic magnetic therapy in CNS function, performance on memory and attention tests, state of autonomic nervous system and psychoemotional state of patients (the reduction of anxiety and depression).
PMID: 18833174 PubMed - as supplied by publisher
Pulsed Magnetic Therapy
magnetic therapy
Popularity: 44% [?]
